IQOXE has inherited its tradition from former company IQA, which started to function in 1964. It held various shares in a series of chemical multinationals (Shell, Explosivos Rio Tinto, Hoescht, Cepsa). It also possessed a unit dedicated to naphta cracking.
It gradually set up new production plants and by 1967 it was able to produce 460,000 t/y of a dozen chemical derivatives with the help of 446 employees.
The current plant dedicated to the production of ethylene oxide and glycols was set up in 1978.
In 1985, the multinational Shell acquired 100% of the company shares which had been previously sold to La Seda de Barcelona in 1995.
More recently, in April of 2014, CL Grupo Industrial acquired the productive assets of LSB. The new company then became IQOXE.